The MESO-BRAIN project aims to develop functional, three dimensional human stem cell-derived neural networks of defined and reproducible architecture, based on a brain cortical module that displays in vivo connectivity and activity.

The networks will be seeded on nanoscale designed femtosecond laser printed scaffolds using novel polymerisation methods, which will allow electrical simulation, simultaneous recording and light sheet imaging during development and at maturation.

The project concept is to advance the neuroscience research and pharmaceutical drug discovery. The Consortium envisage that within 15 years, these iPSC (induced pluripotent stem cells) derived networks from individual patients will be re-implanted to treat conditions such as Parkinson’s disease, dementia and physical trauma.