The video provides an instructive example of the enabling power of well-engineered 3D scaffold platforms. An iPSCs-derived neuronal cell network developed on 3D laser produced scaffold at day 69 of neuronal differentiation is presented. The video has been reconstructed from a stack of confocal microscopy images. Neurons are green (MAP2 staining), red dots are synaptic connections (PSD95 staining ), and blue are cell nuclei. Laser structured 3D scaffold represent a great artificial platform for the development of 3D neuronal networks. Obtained neuronal cell populations are currently undergoing thorough characterization using additional markers.
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The MESO-BRAIN project met in the splendid setting of the Medical School Buildings at the University of Barcelona for a review of progress at the end of Year 2 and planning for the final 12 months of the project.
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As the project heads into the last 12 months of activity, recent recordings of Axol iPSC cell cultures show great promise for the achievement of the final results.
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FENS, The Brain Prize and IBRO-PERC stipend recipient, James Crowe attended The Brain Conferences: Cortex Development and Evolution (FENS), which took place in Copenhagen, Denmark. James is a PhD candidate at the Department of Life and Health Sciences, Aston University, UK. His research focuses upon building human cortical networks-in-a-dish using iPSC-derived neural stem cells, with the aim of exploring network connectivity. James discusses his attendance of the conference where he presented his research.
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A PhD candidate working on the MESO-BRAIN project, James Crowe attended the Photonics meets Biology summer school IV (PMB IV), which took place in Tarragona, Spain. James discusses his attendance of the conference where he presented his research. This year’s biennial Photonics meets Biology summer school was held in the Catalonian city of Tarragona. The summer schools brings together expertise in leading-edge research, and focuses on the union of photonic and biological sciences to revolutionise the use of lasers in the biomedical field.
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Prof Eric Hill from Aston University explains at Birmingham News how new brain cell scaffolds could provide clues to help develop therapies for Alzheimer’s disease.
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Axol Bioscience have successfully developed red fluorescent, Genetically-Encoded Ca2+ indicator for Optical imaging (R-GECO) and imaged iPSCs with R-GECO integrated in multiple locations of the genome.
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In Tarragona on the 18th September, the interdisciplinary consortium met to present and discuss their latest results and agree future research priorities. The meeting was hosted by the Institute of Photonics Sciences.
Birmingham scientists who are growing human brain cells in the laboratory say their work could one day help combat the damage caused by Alzheimer’s and other brain traumas.
Continue reading “Scientists grow human ‘mini brains’ – MESO-BRAIN features in Medical Express”
BIRMINGHAM, CAMBRIDGE, HUDDERSFIELD (UK), HANNOVER (Germany), BARCELONA (Spain), 9 June 2016: The MESO-BRAIN consortium has received a prestigious award of €3.3 million in funding from the European Commission as part of its Future and Emerging Technology (FET) scheme. The project aims to develop three-dimensional (3D) human neural networks with specific biological architecture, and the inherent ability to interrogate the network’s brain-like activity both electrophysiologically and optically. It is expected that the MESO-BRAIN will facilitate a better understanding of human disease progression, neuronal growth and enable the development of large-scale human cell-based assays to test the modulatory effects of pharmacological and toxicological compounds on neural network activity. The use of more physiologically relevant human models will increase drug screening efficiency and reduce the need for animal testing.
Continue reading “Meso-brain initiative receives €3.3 million to replicate brain’s neural networks through 3D nanoprinting”